Although the presently preferred embodiment of the invention contemplates using the phosphodiesterase inhibitor sildenafil citrate as the preferred energetic for the strategies set forth herein in the therapy and/or prevention of EIPH, it is specifically contemplated that other phosphodiesterase inhibitors are within the scope of the invention. Specifically, the invention relates to methods and gadgets for nebulization therapy in horses for the remedy and prevention of respiratory circumstances together with Exercise-Induced Pulmonary Hemorrhage (EIPH) and related pulmonary sequella within the horse. The foregoing and other objects, options and advantages of the current invention should turn into obvious to those of talent within the art in the next description when taken together with the accompanying drawings and by way of practice of the invention. Accordingly, there nonetheless exists a necessity in the art for such strategies. In the embodiment shown, in FIG. 1, the system 10 and attachment means 20 are proven connected to the top 30 of the topic equine and mendacity beneath a typical equine halter 60. Thus, one of skill within the art can respect that the gadget 10 and attachment means 20 will be connected and used independent of however together with halters, bridles or other equine head gear.

Within the embodiment proven in FIG. 1, the attachment means 20 itself is a halter-sort or halter-like apparatus constructed of nylon or leather with adjustable straps for securing to the pinnacle 30 of the topic equine and is separate from halter 60. As set forth more filly below, the attachment means 20 for the device 10 can be separate from halter 60 or built-in therein. The machine 10 or equine nasal cannula might be designed to conform to or become an integral a part of harness and/or bridle or other halter-type equipment usually related to the coaching and racing of equine athletes. Thus, the present invention offers an inhalation therapy regimen administered via, e.g., a non-invasive equine nasal cannula gadget as also offered by the invention. In a presently most popular embodiment, the invention provides a technique for the therapy or prevention of EIPH, whereby the composition for inhalant therapy is a mixture comprised of sildenafil citrate or its congeners (e.g., metabolites, isomers, salts or different active derivatives of sildenafil citrate) using air as the delivery automobile to hold the inhalant into the equine mammal. In one embodiment, the therapy regimen includes the introduction of a composition comprised of sildenafil citrate or congeners of sildenafil citrate with or with out potentiating agents delivered to the subject equine via the attendant inhalation therapy system in a non-invasive method that is conducive to the care and consolation of the equine mammal under treatment.

The gadget 10 is held in place by attachment means 20 such that the distal ends 16, 18 of elongated supply tubes 12, 14 (cannulas) are placed adjacent the external openings 32, 34 of the topic equine's nasal cavity (adjoining the nares) so as to successfully ship the composition selected for inhalation at the appropriate site. Within the presently preferred embodiment, the gadget 10 of the invention (the equine nasal cannula) is comprised of a nylon attachment means 20 (just like a halter) that's configured to adapt to the contours of the equine skull 30 in such a fashion as to effectively place and hold the distal ends 16, 18 of the elongated delivery tubes 12, 14 in a desired position for the administration of a therapeutic inhalant whereas minimizing the necessities for specialised animal restraint and/or restriction of motion. In one embodiment, padded extrusions (not proven) are offered at the distal ends 16, 18 (nasal end) of the elongated tubes 12, 14 (cannulas) to stop harm or irritation that will occur from rubbing the nostrils or the inside linings (mucosa) of the nostrils.

Thus, the dimensional and other traits proven in FIGS. FIG. 5 is a perspective view of 1 embodiment of the nebulization apparatus and air supply for supply of a desired therapeutic agent via the system of FIGS. FIG. Three is a perspective view of 1 embodiment of the nasal cannula portion of the machine of the invention. FIG. 7 is a colour digital photograph displaying a left frontal view of 1 embodiment of the system of the invention. It's an object of the invention to supply an inhalation therapy regimen and system for the treatment and/or prevention of EIPH comprising the inhalation of a therapeutic quantity of sildenafil citrate and/or the metabolites of sildenafil citrate alone or in combination with other compounds. Studied for its immune well being advantages, N-Acetyl-L-Cysteine 98% bulk pricing defends towards insults from overseas compounds. Generally speaking, simple organic compounds formed by the substitute of a hydrogen atom of hydrogen sulfide by an aliphatic, aromatic or heterocyclic radical are referred to as "thiols," e.g. methanethiol; whereas, polyfunctional compounds so formed are sometimes described with the prefix "mercapto," equivalent to mercaptoacetic acid.